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Freddie Prinze Jr.
Pi (voice)

Rob Schneider
Nerissa (voice)

Evan Rachel Wood
Cordelia (voice)

Donal Logue
Troy (voice)

Andy Dick
Dylan / Curious Shark (voice)

Fran Drescher
Pearl (voice)

John Rhys-Davies
Thorton (voice)

R. Lee Ermey
Jack (voice)

Dylan Cash
Young Percy (voice)

Bruno Alexander
Pi's Dad (voice)

David Fickas
Max / Squid No. 3 / Big Shark (voice)

Jimmy Bennett
Young Pi (voice)

Megahn Perry
Percy's Mum / Female Parrotfish (voice)

Mel Rodriguez
Manny / Dr. Tang (voice)

Reedy Gibbs
Pi's Mom (voice)

Richard Epcar
Moe (voice)